RFX1 — Candida albicans

Summary

CR_06110C_A (RFX1, also known as CaSAK1 or CaRFX1) on Candida albicans chromosome 8 encodes a DNA-binding transcription factor of the RFX-like family, with both activator and repressor activities annotated for RNA polymerase II-specific transcription. The gene is associated with regulation of transcription, DNA repair, the DNA damage response, cell cycle, morphogenesis, filamentous growth, cell aggregation, gluconeogenesis, the glyoxylate cycle, and innate immunity. It is associated with downregulation of cell adhesion and upregulation of DNA repair. The encoded protein localises to the nucleus, cytoplasm, and chromatin. Related genes in other species encode RFX-type winged-helix domain-containing proteins, and the family is linked to turgor pressure, though this has not been established in C. albicans.