HH3 — Candida albicans

Summary

CR_06810W_A (HH3, also known as HHT2) on chromosome 8 of Candida albicans encodes a histone H3/CENP-A family protein with a histone-fold domain. The product is a structural constituent of chromatin, binds nucleosomal DNA, and exhibits protein heterodimerization and DNA-binding activities. HH3 is associated with centromere localization and separation, kinetochore assembly, mitotic metaphase chromosome alignment, and fungal-type cell wall assembly. It is linked to cell cycle progression, particularly through the G2/M and G1/S phase transitions, as well as anaphase, metaphase, and telophase timing. The gene has been connected to chromosome segregation, mating type switching, meiosis, sporulation, gene conversion, chromatin silencing, and methylation. Phenotypic associations include altered cell cycle progression, increased nutrient uptake, decreased hypoosmotic stress resistance, increased gamma ray resistance, and abnormal mitophagy.