EFG1 — Candida albicans

Summary

CR_07890W_A (EFG1, also known as PAN1) on Candida albicans chromosome 8 encodes a DNA-binding transcription activator of the APSES-type helix-turn-helix family, localised to the nucleus and chromatin. The gene is associated with filamentous development, cellular developmental processes, and responses to farnesol, hypoxia, staurosporine, and N-acetyl-D-glucosamine. It is linked to farnesol and carnitine anabolism, proline breakdown and metabolism, carbohydrate storage, cell migration, bioluminescence, siRNA-mediated post-transcriptional gene silencing, and anti-inflammatory and leukocyte adhesion responses. Associations with traits include polysaccharide content, calcium sensitivity, and oxidative stress response. Phenotypic links include abnormal filamentous growth, bipolar budding, cytokinesis, cell fusion, shmoo formation, autophagy, necrotic cell death, endocytosis, hyperosmotic stress resistance, prion inheritance and formation, and cell cycle progression through G2/M. The gene is also connected to denture stomatitis and invasive candidiasis.