TRK — Candida albicans

Summary

CR_07960C_A (TRK1) in Candida albicans encodes a potassium transporter belonging to the Trk/HKT family, with high-affinity potassium ion transmembrane transporter activity and chloride transmembrane transporter activity. The gene is associated with potassium ion import across the plasma membrane, cellular potassium ion homeostasis, cell volume homeostasis, regulation of membrane potential, and response to toxic substances and cation stress. TRK1 is associated with cell growth, protein folding, sterol anabolism, and cell cycle progression, with observed abnormal anaphase progression, increased M phase progression, and absent meiosis. Phenotypic associations include increased anaerobic growth, absent desiccation and hyperosmotic stress resistance, increased freeze-thaw resistance, and altered endocytosis rates. The protein localizes to the plasma membrane, cell tip, cell division site, and Golgi complex. Studies of related genes in other species link the family to potassium content and sodium uptake.