FHPA — Candida albicans

Summary

CR_10570C_A (FHPA, also known as YHB4) on Candida albicans chromosome 8 encodes a nitric oxide dioxygenase with NAD(P)H activity, a heme- and FAD-binding globin-domain protein that localises to mitochondria, cytoplasm, cytosol and nucleus. The gene is associated with nitric oxide breakdown, response to nitrosative and oxidative stress, alternative respiration, glyoxylate cycle regulation, gluconeogenesis, biofilm formation, germ tube formation, phenotypic switching, cell adhesion, phagocytosis, sterol metabolism and heterotrophy. Phenotypic associations include decreased fermentative and respiratory metabolism, increased pheromone sensitivity and mating response, increased flocculation, abnormal budding, increased autophagy, decreased gamma ray resistance, increased hyperosmotic stress resistance, absent pseudohyphal growth, decreased survival in stationary phase, increased mitotic recombination and telomere length, and cell cycle arrest at both G1 and G2/M phases. Related genes in other species link the family to reduced virulence and oxidative stress response.