PST1 — Candida albicans

Summary

C1_00930C_A (PST1, also known as SIN3) in Candida albicans encodes a Sin3-like protein containing PAH domains and an HDAC interaction domain, with transcription corepressor activity, transcription coactivator activity, DNA binding transcription factor activity, identical protein binding, DNA binding, and binding, bridging activities. The gene is associated with negative regulation of transcription by RNA polymerase I, negative regulation of chromatin silencing at silent mating-type cassette, rDNA packaging, and negative regulation of phospholipid anabolism. It is also associated with the oxidative stress response, increased virulence, abnormal mating-type switching, altered cell cycle progression, delayed exit from G0, increased rate of nutrient uptake, and premature protein/peptide accumulation. The product localizes to the nucleus, chromatin, cytosol, centric heterochromatin, and the Clr6-LE complex. Related genes in other species connect it to the Rpd3S and Rpd3C(L) complexes and response to pH.