GAL1 — Candida albicans

Summary

C1_02130C_A (GAL1) on Candida albicans chromosome 1 encodes a galactokinase (EC 2.7.1.6) with a GHMP kinase domain, conferring galactokinase activity and ATP binding. The gene is associated with the Leloir pathway, galactose breakdown and metabolism, galactose transmembrane transport, lactose metabolism, catabolite repression, and the glucose effect. It has been linked to macrophage activation, cytokine production, phagocytosis, phenotypic switching, fluconazole transport, protein secretion, mitotic recombination, gene conversion, and heterotrophy. Associations with carbon source utilization, fermentative growth, mating type switching, adhesion, spore germination, chromosome segregation, cytokinesis, flocculation, and responses to UV, alkaline pH, cold, and hydrostatic pressure have been reported. The product localizes to the cytoplasm and cytosol. Studies of related genes in other species link the family to galactose utilization.