PDE2 — Candida albicans

Summary

C1_02840W_A (PDE2, CaPDE2) on chromosome 1 of Candida albicans encodes a cyclic-nucleotide phosphodiesterase with cGMP and cAMP-specific phosphodiesterase activity, metal binding, and a PDEase catalytic domain. The gene is associated with negative regulation of cAMP/PKA signaling, regulation of morphogenesis, germ tube formation, flocculation, quorum sensing, cell adhesion involved in single-species biofilm formation, membrane biogenesis, plasma membrane organization, cellular response to carbon dioxide, response to neutral pH, and downregulation of phenotypic switching. Phenotypic associations include increased adhesion, increased thermotolerance, increased fermentative and anaerobic growth, abnormal pseudohyphal growth, abnormal respiratory metabolism, and altered cell cycle progression including G2/M phase transition defects and anaphase arrest. Related genes in other species link the family to oxidative stress response and acid sensitivity.