SKO1 — Candida albicans

Summary

C1_03770W_A (SKO1) in Candida albicans chromosome 1 encodes a bZIP transcription factor with DNA-binding transcription activator activity specific to RNA polymerase II, along with nucleosome binding, recombination hotspot binding, and chromatin adaptor functions. The gene is associated with stress-activated MAPK cascade, TOR signaling, protein kinase A and PKC activation, osmotic response, glycerol anabolism, flocculation, cell-cell adhesion, vacuolar transport, oxidative phosphorylation, and regulation of filamentous growth and meiotic recombination. It localizes to the nucleus, chromatin, heterochromatin, and the Atf1-Pcr1 complex. SKO1 is linked to infection in Galleria mellonella and Mus musculus models, and to oxidative stress response. Studies of related genes in other species connect the family to blue mold, invasive pulmonary aspergillosis, and vascular wilt.