ACUD — Candida albicans

Summary

C1_04500W_A (ACUD, ICL1) in Candida albicans encodes an isocitrate lyase with methylisocitrate lyase activity and metal binding capability, placing it at the junction of the glyoxylate cycle, gluconeogenesis, and fatty acid beta-oxidation. The gene is associated with carbon catabolite repression, response to glucose and fructose, acetate breakdown, ATP anabolism, biofilm formation, and phagocytosis. The product localizes to the glyoxysome and peroxisome. Phenotypic associations link ACUD to increased hydrostatic pressure and alkaline pH resistance, increased respiratory metabolism and stationary phase entry, decreased apoptosis and cold sensitivity, abnormal cell wall morphology and budding pattern, and altered cell cycle progression. The gene is also connected to candidiasis and disseminated candidiasis. Studies of related genes in other species link the family to survival rate in stationary phase and unaffected pathogenicity.