UME6 — Candida albicans

Summary

UME6 (C1_06280C_A) in Candida albicans chromosome 1 encodes a protein with a STE20 Ser/Thr kinase domain and a Zn2Cys6 DNA-binding domain, and has been annotated as a DNA-binding transcription activator. The gene is associated with filament development, upregulation of filamentous growth, mating projection assembly, cell motility, and spindle orientation. It is also linked to seed growth and germination, fatty acid oxidation, arginine and amino acid breakdown, cellular response to carbon dioxide, membrane depolarization and fission, mitochondria depolarization, bioluminescence, cell fate specification, and inflammatory response. The encoded protein localizes to the nucleus. UME6 is associated with invasive and disseminated candidiasis, and with traits including polysaccharide content, calcium sensitivity, and oxidative stress response. Related genes in other species are linked to relative growth rate.