CDC3 — Candida albicans

Summary

C1_08030W_A (CDC3, also known as PFY1) in Candida albicans encodes a profilin family protein that binds G-actin, proline-rich regions, and phosphatidylinositol (4,5)-bisphosphate. This gene is associated with actin polymerization and depolymerization, cytokinesis, cytogamy, biofilm formation, pseudohyphal and invasive growth, sporulation, and fungal-type cell wall organization. It localizes to the actin patch, medial ring, cell cortex, mating projection tip, and fungal biofilm matrix. Associations include abnormal filamentous growth, cell cycle arrest at multiple phases, delayed vegetative growth and protein secretion, and abnormal prion inheritance and formation.