ABC2 — Candida albicans

Summary

C1_08210C_A (symbol ABC2, also known as MLT1) encodes an ABC transporter with ATP hydrolase activity, haem-transporting ATPase activity, and cadmium ion transmembrane transporter activity, and belongs to the ABCC subfamily. The gene is associated with multiple cellular processes including fluconazole transport, glutathione transport into the vacuole, heme export from vacuole to cytoplasm, phospholipid transport, ergosterol metabolism, germ tube formation, and cellular detoxification of cadmium ion. It is linked to the fungal-type vacuole membrane, Golgi complex, and plasmalemma. Associations with traits include oxidative stress response. The gene is also connected to candidiasis and has been studied in relation to vacuolar morphology, endocytosis, cell cycle progression, and pexophagy.