ENO1 — Candida albicans

Summary

ENO1 (C1_08500C_A) on Candida albicans chromosome 1 encodes an enolase with phosphopyruvate hydratase activity (EC 4.2.1.11) and transglutaminase activity, and binds melatonin, host kininogen and magnesium. The enolase is localised to the cell wall, plasma membrane, extracellular vesicles and biofilm matrix. ENO1 is associated with glycolysis, germ tube formation, host immune response perturbation, inflammatory response, B cell activation, IL-6 production, fibrinolysis, clotting, angiogenesis, phagocytosis, metabolic burst, memory, vacuole fusion regulation, and fungal-type cell wall organisation. Phenotypic associations include abnormal filamentous growth, increased adhesion, absent innate thermotolerance, decreased fermentative metabolism and growth, increased respiratory metabolism, increased cell death, abnormal cytokinesis, and increased critical cell size at the G1 checkpoint. Studies of related genes in other species link the enolase family to glycolysis and cell wall integrity.