AOX — Candida albicans

Summary

C1_09150W_A (AOX2) on Candida albicans chromosome 1 encodes an alternative oxidase (AOX_sf family) with alternative oxidase activity and metal binding, localised to the mitochondrial inner membrane and respirasome. This gene is associated with alternative respiration, electron transport chain, and programmed cell death, as well as biofilm formation, immune evasion, phagocytosis, and disseminated candidiasis in a mouse model. It is also linked to cellular response to iron, gluconeogenesis, and metabolism of nucleotides, cAMP, ATP, mannan, methanol, sphingolipids, and sterols. Studies of related genes in other species connect the family to oxidative stress response.