URA1 — Candida albicans

Summary

C1_09720W_A (URA1) on Candida albicans chromosome 1 encodes a dihydroorotate dehydrogenase, as indicated by its dihydroorotate dehydrogenase activity (EC 1.3.5.2) and its localization to the mitochondrial inner membrane. The gene is associated with uridine and pyrimidine ribonucleotide anabolism, as well as de novo UMP biosynthesis. URA1 is also associated with regulation of morphogenesis, phenotypic switching, and responses to cyclophosphamide and methyl methanesulfonate. It is linked to inflammatory and immune responses, cytokine production, and phagocytosis. Phenotypic associations include increased adhesion, abnormal colony color and cellular morphology, decreased acquired thermotolerance and respiratory growth, increased cell size, and altered RNA accumulation. Studies of related genes in other species link the family to oxidative stress response and anaerobic growth.