RTG3 — Candida albicans

Summary

C1_10990C_A (RTG3, CaRTG3) in Candida albicans encodes a basic helix-loop-helix (bHLH) transcription factor with DNA-binding transcription activator activity, protein dimerization activity, and RNA polymerase II-specific cis-regulatory region binding. The gene is associated with alternative respiration, metabolic burst, methanol metabolism, mannan anabolism, galactose breakdown, sphingolipid metabolism, cellular response to reactive oxygen species, electron transport chain, TCA cycle, biofilm formation, mitophagy, and regulation of transcription. Phenotypic associations link RTG3 to increased nutrient uptake and carbon source utilization, decreased cell death, altered cell cycle progression (increased G1 and G2/M phase transitions, premature metaphase and telophase), increased survival in stationary phase, increased fermentative metabolism, and increased ionic stress resistance, alongside absent adhesion, hyperosmotic stress resistance, UV resistance, and late nucleophagy. The protein localizes to both cytoplasm and nucleus.