YSF3 — Candida albicans

Summary

CaYSF3 (C1_11680C_A) on Candida albicans chromosome 1 encodes a protein belonging to the SF3b5/RDS3-10 domain family, a component of the U2 snRNP and precatalytic spliceosome. The gene is associated with mRNA splicing via the spliceosome, biofilm formation, filamentous and invasive growth, morphogenesis, secretion, proteolysis, cell cycle, and homeostasis. It is also linked to innate immunity, NK cell activation, phagocytosis, fibrinolysis, and blood clotting. Phenotypic associations include decreased RNA modification and autophagy, increased colony sectoring and heat sensitivity, altered competitive fitness and chemical resistance, and haploinsufficiency or inviability. Studies of related genes in other species link the family to pre-mRNA processing.