HYR1 — Candida albicans

Summary

HYR1 (C1_13450W_A) on Candida albicans chromosome 1 encodes a hyphal-regulated cell wall protein containing a Hyphal-reg_cell_wall_N domain. The product is associated with HK binding and localizes to the hyphal cell wall, fungal-type cell wall, side of membrane, plasma membrane, and extracellular. This gene is linked to numerous host interaction processes including response to host, mitigation of host defenses, host invasion, germ tube formation, biofilm formation in or on the host, cell-substrate adhesion, and tube formation. It has also been connected to immune-related processes such as T cell polarization, opsonization, cytokine production, inflammatory response, phagocytosis, immune response, and memory, as well as wound healing, digestion, cell polarization, and phosphate metabolism. Related genes in other species link the family to candidiasis and unaffected pathogenicity.