SOD6 — Candida albicans

Summary

C2_00240C_A (SOD6) on Candida albicans chromosome 2 encodes a copper/zinc superoxide dismutase (EC 1.15.1.1) with superoxide dismutase activity and copper binding, belonging to the SOD_Cu/Zn/chaperone family. The product is associated with cellular response to superoxide, superoxide metabolism, evasion or tolerance of host-produced AOS, removal of O2-, immune evasion, biofilm formation, cellular response to oxidative stress, DNA replication, and homeostasis. It localizes to the yeast-form cell wall, hyphal cell wall, side of membrane, extracellular vesicle, fungal-type cell wall, cell-bound, and extracellular compartments. The gene is also linked to oxidative stress response. Studies of related genes in other species connect this family to loss of pathogenicity and reduced virulence, as well as associations with candidiasis and disseminated candidiasis.