MSB2 — Candida albicans

Summary

C2_01780W_A (MSB2) on Candida albicans chromosome 2 encodes an MSB2 family protein with osmosensor activity. The gene is associated with osmosensory signaling via the Sho1 osmosensor, the HOG response, and stimulation of the MAPK cascade, as well as protein kinase A activation. It has been connected to filamentous growth of a population of unicellular organisms, upregulation of single-species biofilm formation on inanimate substrates, and cellular bud site selection. Additional associations include cell wall biogenesis, fungal-type cell wall organization, cellular response to heat, protein folding, cytokine production, and immune response. The product localizes to the site of polarized growth, the plasmalemma, extracellular vesicles, and is found both cell-bound and extracellular.