VAM6 — Candida albicans

Summary

CaVAM6 (C2_02440W_A) on Candida albicans chromosome 2 encodes a protein containing Vam6/VPS39/TRAP1, VPS39/TGF_beta_rcpt-assoc_1, VPS39/TGFA1_Znf and CNH domains. The product binds small GTPases and is associated with GDS activity. It is linked to vacuole fusion, upregulation of TORC1 signaling, mitophagy, autophagy, intracellular protein transport, vesicle transport, filamentous growth, hyphal growth, and response to oxidative stress. The protein localises to the HOPS complex, vCLAMP, vacuolar membrane, endomembrane system, cytoplasm, cytosol, and nucleus. CaVAM6 has been connected to oral candidiasis in a mouse model. Studies of related genes in other species link the family to fungal development and pathogenicity.