ERG10 — Candida albicans

Summary

C2_04310W_A (ERG10) in Candida albicans encodes an acetyl-CoA C-acetyltransferase (EC 2.3.1.9) belonging to the thiolase family, with metal-binding activity. The gene is associated with multiple metabolic processes, including the isoprenoid pathway, fatty acid beta-oxidation, sterol and ergosterol anabolism, fatty acid anabolism, fermentation, morphogenesis, and ribosome biogenesis. Its product localizes to the peroxisome, mitochondria, and cytosol. ERG10 is linked to diverse phenotypes such as altered cell cycle progression (including premature metaphase-anaphase transition and abnormal G2 phase), decreased freeze-thaw resistance, increased resistance to enzymatic treatment, increased transposable element transposition, decreased telomere length, increased cell size, altered replicative lifespan, and abnormal sporulation and meiosis. Studies of related thiolase family members in other fungi connect the family to lethal phenotypes and abnormal cytokinesis.