ADH1 — Candida albicans

Summary

Candida albicans gene C2_04480W_A, symbol ADH1 on chromosome 2, encodes a protein with aldo-keto reductase (NAD) and oxidoreductase activity acting on NAD(P)H, containing ADH-like and NAD(P)-binding domains. The gene is associated with glycolytic process, ethanol metabolism, methylglyoxal anabolism, and reactive oxygen species metabolic process. It is linked to germ tube formation, tube formation, inflammatory response, immune evasion, and clotting. Associations also include response to cadmium, nitrogen catabolite repression, amino acid breakdown, arginine metabolism, and glutathione anabolism. The product localizes to the cytoplasm, mitochondrial lumen, extracellular region, and fungal biofilm matrix. Studies of related genes in other species link the family to alcohol dehydrogenase (EC 1.1.1.1) activity.