PAR1 — Candida albicans

Summary

C2_06420C_A (PAR1/RTS1) in Candida albicans encodes a protein with a PP2A_B56 domain and an ARM-type fold, and is annotated with protein phosphatase activator activity, protein binding bridging, and DNA binding. The gene is associated with cell cycle progression, including decreased rate of progression, premature metaphase-anaphase transition, and altered durations of M phase stages. It is linked to chromosome biorientation, meiotic sister chromatid cohesion, septin ring organization and disassembly, cell morphogenesis, and protein localization to chromosomes. Localization evidence places the product at the PP2A complex, kinetochore, meiotic spindle, spindle pole body, cellular bud neck, and cell tip. Phenotypic associations include decreased autophagy and pexophagy, increased mating type switching, absent X-ray resistance, abnormal sporulation efficiency, and decreased hypoosmotic stress and alkaline pH resistance. Studies of related genes in other species link the family to potassium concentration and oxidative stress response.