OBR1 — Candida albicans

Summary

C2_06870C_A (OBR1, also known as PST1) on Candida albicans chromosome 2 encodes a flavoprotein of the WrbA-like family with NAD(P)H dehydrogenase (quinone) activity (EC 1.6.5.2), specifically 2-hydroxy-1,4-benzoquinone reductase activity, and binds FMN. The gene is associated with plasma membrane organization, immune response, response to stress, secretion, endocytosis, cell cycle modulation, and morphogenesis. Its product localizes to the eisosome, hyphal cell wall, fungal biofilm matrix, plasma membrane, cytoplasm, and nucleus. OBR1 is linked to numerous phenotypes including abnormal cell cycle progression (G1/S, S, metaphase-anaphase, anaphase, telophase), increased sporulation, altered mutation frequency, increased cell death, increased freeze-thaw resistance, altered UV resistance, decreased chitin deposition, and abnormal plasma membrane morphology. Studies of related genes in other species link the family to loss of pathogenicity and decreased survival in stationary phase.