OS-5 — Candida albicans

Summary

C2_08860W_A (CaOS-5) on Candida albicans chromosome 2 encodes a protein serine/threonine kinase with ribosomal protein S6 kinase activity, signaling adaptor activity, lipid binding, and identical protein binding. It is associated with the RAM/MOR signaling pathway, regulation of protein secretion, lipid raft organization, filamentous growth, biofilm formation, exocytosis, glycerol anabolism, actin cortex stabilization, microtubule dynamics, and responses to pheromone, heat, and salinity. The protein localizes to growing cell tips, hyphal tips, bud tips, bud necks, the cell cortex, and nucleoplasm. Phenotypic associations include increased thermotolerance, altered cell cycle progression, increased adhesion and fermentative growth, abnormal carbon source utilization, and absent mating efficiency, apoptosis, desiccation resistance, hyperosmotic stress resistance, and pheromone sensitivity.