NOP7 — Candida albicans

Summary

C2_09320C_A (NOP7, also known as PES1 or PPP1) on Candida albicans chromosome 2 encodes a protein containing a PES domain and a BRCT domain, with RNA binding, 25S rRNA binding, identical protein binding and RNP binding activities. The gene is associated with ribosome biogenesis, particularly the maturation of 5.8S, LSU and SSU rRNAs from tricistronic transcripts, and localises to the nucleoplasm and the large subunit preribosome. NOP7 is associated with cell cycle control, mitotic exit, morphogenesis, filamentous growth, hyphal growth, biofilm formation, sporulation, and cellular responses to starvation and xenobiotic stimuli. Associations with decreased exponential-phase growth, delayed cytokinesis, altered cell cycle progression through G1/S and G2/M phases, increased ionic stress resistance, decreased chitin deposition, and abnormal chronological lifespan have been observed. Related genes in other species connect the family to the PeBoW complex.