GPD1 — Candida albicans

Summary

C2_10240W_A (GPD1) in Candida albicans chromosome 2 encodes a glycerol-3-phosphate dehydrogenase [NAD(P)+] (EC 1.1.1.8), with NAD binding and protein homodimerization activity. The gene is associated with glycerol-3-phosphate breakdown and metabolism, glycerol anabolism, fermentation, carbohydrate metabolism, morphogenesis, cell cycle modulation, osmotic response, immune evasion, and host response, including symbiont-mediated suppression of host complement activation and clotting. It is linked to cell-abiotic substrate adhesion and localizes to the cytosol, nucleus, peroxisome, fungal-type cell wall, extracellular vesicle, and biofilm matrix. Phenotypic associations include decreased hypoosmotic and hyperosmotic stress resistance, absent desiccation resistance, altered cell cycle progression, increased anaerobic and fermentative growth, and abnormal peroxisomal morphology and distribution.