HOS2 — Candida albicans

Summary

Candida albicans gene HOS2 (CaHOS2) on chromosome 3 encodes a histone deacetylase with NAD-independent activity, specifically deacetylating histones H3-K9, H3-K14, H4-K5, H4-K8, H4-K12, and H4-K16, as well as possessing tubulin deacetylase activity. The product belongs to the histone deacetylase family and binds chromatin and identical proteins. HOS2 is associated with epigenetic regulation of gene expression, heterochromatin island and rDNA heterochromatin assembly, centromeric silencing, and regulation of phenotypic switching. It is linked to filamentous growth in response to pH and starvation, positive regulation of p38 MAPK signaling, and downregulation of meiosis and transcription. Phenotypic associations include increased aneuploidy, decreased colony size, absent adhesion and mating response, increased meiotic recombination, altered sporulation rates, and changes in nutrient uptake, carbon source utilization, and stress resistance. The protein localizes to multiple HDAC complexes including HDA1, Rpd3S, SHREC, SET3C, and euchromatin. Related genes in other species include SET3.