POX1 — Candida albicans

Summary

Candida albicans POX1 (C3_01960C_A, also known as CaPOX1) encodes an acyl-CoA oxidase (EC 1.3.3.6) localized to the peroxisomal lumen. The gene is associated with acyl-CoA oxidase activity, fatty acid binding, FAD binding, eoxin synthesis, fatty acid beta-oxidation using acyl-CoA oxidase, arachidonic acid metabolism, prostaglandin anabolism, lipid homeostasis, fatty acid breakdown, biofilm formation, homologous recombination, fermentation, and cell cycle. Phenotypic associations link the gene to peroxisomal transport and morphology, nutrient uptake and utilization, carbon source utilization, respiratory growth, chronological and replicative lifespan, starvation resistance, metal resistance, innate thermotolerance, survival rate in stationary phase, vegetative growth, filamentous growth, invasive growth, biofilm formation, protein/peptide distribution and accumulation, protein activity, RNA accumulation, chromosome/plasmid maintenance, and haploid proficiency. Studies of related acyl-CoA oxidase genes in other species connect the family to oxidative stress response, acid sensitivity, and sporulation efficiency.