KRE6 — Candida albicans

Summary

Candida albicans gene KRE6 (also known as SKN2) on chromosome 3 encodes a protein with glucosidase activity, belonging to the GH16 domain and ConA-like domain superfamily. The gene is associated with cell wall organization and biogenesis, including 1,6-beta-glucan and chitin anabolism, as well as regulation of cytoskeleton organization, biofilm formation, hyphal growth, morphogenesis, ergosterol anabolism, and cell death. It localizes to the Golgi membrane, endoplasmic reticulum, and plasma membrane. Phenotypic associations include abnormal cell cycle progression, cytokinesis, thermotolerance, cell fusion, endocytosis, filamentous growth, mating, and increased polyploidy. Studies of related genes in other species link the family to beta-glucan synthesis, virulence, and pathogenicity.