PRP2 — Candida albicans

Summary

CaPRP2 (C3_04230W_A) encodes a DEAD/DEAH-box RNA helicase with 3'-5' RNA helicase activity, ATP binding and hydrolysis, and ribosomal small subunit binding. It is associated with spliceosome complex disassembly, formation of catalytic spliceosomes for both transesterification steps, and protein-RNA complex organization. The gene is linked to cell cycle regulation, including abnormal G2/M phase transition, S phase arrest, and delayed exit from G0, as well as abnormal spindle morphology, chromosome segregation defects, and increased shmoo formation and absent nuclear fusion. Associations also include abnormal carbon source utilization, increased X-ray resistance, and altered RNA modification and accumulation. The product localizes to the spliceosome, nucleolus, and chromatin. Studies of related genes in other species connect it to ribosome biogenesis.