ABCA — Candida albicans

Summary

C3_04890W_A (symbol ABCA, also known as CDR2) in Candida albicans encodes a member of the PDR subfamily of ABC transporters, specifically the ABCG_PDR family. The protein exhibits azole transmembrane transporter activity, fluconazole transmembrane transporter activity, and phosphatidylethanolamine floppase activity, among other transport functions. It is associated with response to progesterone, azole transmembrane transport, fluconazole transport, steroidogenesis, germ tube formation, cell aggregation, and membrane polarization. The protein localizes to the plasma membrane, extracellular vesicles, and vacuolar lumen. ABCA is linked to abnormal small molecule transport, decreased vacuolar distribution, increased fermentative growth, abnormal pseudohyphal growth, and altered chronological and replicative lifespan.