CMR3 — Candida albicans

Summary

Candida albicans CMR3 (also known as CRZ1) encodes a C2H2-type zinc-finger protein with DNA-binding transcription factor activity, DNA-binding transcription activator activity, RNA polymerase II-specific, and 14-3-3 protein binding capability. The gene is associated with thigmotropism, PKC signal transduction, cellular responses to cold, acidic pH, calcium ions, and mechanical stimuli, as well as lactate breakdown, regulation of apoptotic process, innate immunity, phagocytosis, regulation of single-species biofilm formation on inanimate substrate, and bipolar bud site selection. CMR3 localizes to chromatin, cytoplasm, cytosol, and nucleus. The gene is linked to calcium sensitivity and numerous phenotypes including abnormal cell cycle progression, decreased radiation and hyperosmotic stress resistance, increased desiccation resistance, abnormal chromosome segregation and nuclear morphology, altered mutation frequency, and reduced anaerobic and respiratory growth. Studies of related genes in other species connect the family to calcineurin-mediated signaling, loss of pathogenicity, and reduced virulence.