MNN9 — Candida albicans

Summary

C3_06020W_A (MNN9, CaMNN9) on Candida albicans chromosome 3 encodes a mannan polymerase subunit with 1,6-alpha-mannosyltransferase and mannosyltransferase activity. The gene is associated with mannan and cell wall mannoprotein anabolism, protein N-linked glycosylation, and fungal-type cell wall organization. MNN9 is linked to filamentous growth, including responses to heat and biotic stimuli, hyphal growth, biofilm formation, phenotypic switching, cell adhesion, and endocytosis. It is also associated with sucrose metabolism, cellular response to heat and xenobiotic stimuli, hypersensitivity, cell death, and homeostasis. The encoded product localizes to the mannan polymerase II complex, mannan polymerase complex, cis-Golgi network, Golgi complex, and ER membrane. Phenotypic associations include decreased mating efficiency and meiosis, abnormal septum formation and endomembrane system morphology, increased biofilm formation and vegetative growth rate, and altered protein secretion and transport.