TPX1 — Candida albicans
Summary
Candida albicans TPX1 (TSA1) encodes a thioredoxin-dependent peroxiredoxin (EC 1.11.1.24) with peroxidase and protein-disulfide reductase activities, belonging to the AhpC/TSA peroxiredoxin family. The gene is associated with cellular responses to hydrogen peroxide, cell redox homeostasis, and programmed cell death, as well as with filamentous growth, cell wall biogenesis, host invasion, and immune response. TPX1 is linked to oxidative stress resistance, adhesion, apoptosis, and cell cycle progression through G2/M phase transition. The encoded protein localises to the cytoplasm, nucleus, and hyphal cell wall. Related genes in other species link the family to mitotic recombination, chromosome segregation, and meiotic recombination.
Annotations
- Chromosome
- 3
- Related genes
- YOR031W, TPX1, TSA1, CTT1, DPB11, MSH6, RAD9, RAD18
- GO terms
- clotting, Immune Response, Biofilm Formation, Asexual Reproduction, Cell Death, Cell Wall Biogenesis, Nucleus, GO:0051082
- Publications
- 28357333, 19214209, 27840029, 34849884, 28383696, 19189942, 19282251, 19359360
- Traits
- RESISTANCE TO CHEMICALS: DECREASED, COMPETITIVE FITNESS: DECREASED, STRESS RESISTANCE: DECREASED, INVIABLE, RESISTANCE TO CHEMICALS: INCREASED, CELL CYCLE PROGRESSION: ABNORMAL, NUCLEAR POSITION: ABNORMAL, ENTRY INTO G0 (STATIONARY PHASE): INCREASED