BSC1 — Candida albicans

Summary

C3_07160W_A (BSC1, also known as PGA32) on Candida albicans chromosome 3 encodes the PGA32 protein. This gene is associated with a wide range of biological processes, including biofilm formation, flocculation, cell adhesion, filamentous and invasive growth, mating, morphogenesis, signal transduction, response to oxidative stress, fermentation, secretion, and TNF production. It is linked to the plasma membrane and the side of the membrane. Phenotypic associations include abnormal or absent biofilm formation and flocculation, increased adhesion and mating efficiency, increased rate of entry into G0, premature meiosis and G1/S transition, delayed cytokinesis, increased polyploidy, and absent toxin, osmotic stress, and oxidative stress resistance. Studies of related genes in other species link the family to flocculin and agglutinin-like domains, as well as to beta-glucan and polysaccharide content.