RLM1 — Candida albicans

Summary

C4_01260W_A (RLM1, CaRLM1) in Candida albicans encodes a MADS-box transcription factor that binds DNA and RNA polymerase II regulatory regions, possesses protein dimerization activity, and localizes to the nucleus, chromatin, nuclear envelope, and cytosol. This gene is associated with cell wall biogenesis, glucan and chitin anabolism, biofilm formation, cell adhesion, flocculation, immune evasion, the TCA cycle, carbohydrate breakdown, secretion, and responses to stress and xenobiotic stimuli. Phenotypic associations include increased virulence, altered polyploidy and aneuploidy, increased anaerobic growth, decreased hypoosmotic stress resistance, increased freeze-thaw resistance, absent desiccation resistance, delayed fermentative metabolism, decreased budding, and abnormal cell cycle progression. Studies of related genes in other species link the family to reduced virulence and loss of pathogenicity.