RBT1 — Candida albicans

Summary

C4_03520C_A (RBT1) on Candida albicans chromosome 4 encodes a protein belonging to the Flo11 flocculin family, with a flocculin type-3 repeat domain, and is annotated with calmodulin (CAM) binding activity. The gene is associated with cell adhesion, particularly in single-species and multi-species biofilm formation, adhesion to host endothelial cells, and cell-cell adhesion. It is associated with filament and germ tube development, cell wall biogenesis, ergosterol metabolism, carbohydrate breakdown, immune evasion, and responses to farnesol and the host. The product localizes to the hyphal cell wall, fungal-type cell wall, mating projection, and extracellular space. Studies of related genes in other species, including HWP1 and HWP2, connect the family to chitin-binding domains and endochitinase-like superfamily, though these associations are not established for RBT1 itself.