CLM2 — Candida albicans

Summary

CaCLM2 (C4_04360W_A) encodes a cytochrome P450 family protein with monooxygenase, oxidoreductase, and phenylacetate hydroxylase activities, and is associated with heme and iron binding. In Candida albicans, this gene is linked to sterol depletion response, zymosterol anabolism, demethylation, prenylation, and phenylacetate breakdown. It is also associated with germ tube formation, inflammatory response, protein oxidation, and mRNA transcription. Phenotypic associations include decreased invasive growth, increased cell death, abnormal cell cycle progression, decreased hyperosmotic stress resistance, and increased fermentative metabolism. The gene is further associated with membrane localisation, protein content, and decreased nutrient uptake. Studies of related genes in other species link the family to sterol biosynthesis pathways, including ERG11 and other ERG family members.