OGM2 — Candida albicans

Summary

C4_04780W_A (OGM2/PMT6) in Candida albicans encodes a protein with protein O-mannosyltransferase activity (EC 2.4.1.109) and is a member of the PMT family localized to the ER and endomembrane system. The gene is associated with protein O-linked mannosylation, mannan anabolism, fungal-type cell wall organization, filamentous growth of a population of unicellular organisms in response to neutral pH and starvation, biofilm formation, cell-substrate adhesion, cytokine production, immune response, and interaction with host. It is linked to candidiasis and has been associated with mannose content, abnormal chitin deposition, septum formation, plasma membrane morphology, and decreased fermentative growth. Related genes in other species are associated with loss of pathogenicity and unaffected pathogenicity, though this has not been established for C. albicans.