EDC3 — Candida albicans

Summary

C4_05190C_A (EDC3, CaEDC3) on chromosome 4 of Candida albicans encodes a protein containing YjeF N-terminal and FDF domains, with phase separation nucleator activity and mRNA binding. It is associated with deadenylylation-independent decapping, P-body and stress granule assembly, and localises to P bodies, stress granules and the cytoplasm. The gene is associated with responses to heat, starvation and oxidative stress, apoptotic and necrotic cell death, filamentous and hyphal growth, sporulation, and virulence. Phenotypic associations include increased virulence, decreased polyploidy, abnormal aneuploidy, decreased mitochondrial transport and nuclear import, increased mitochondrial genome maintenance, absent nuclear fusion during mating, decreased meiotic recombination, abnormal autophagy and absent mitophagy, increased flocculation and exponential-phase growth, and decreased anaerobic and fermentative growth. Related genes in other species connect the family to mRNA decapping and P-body biology.