SOU1 — Candida albicans

Summary

C4_06390W_A (SOU1) on Candida albicans chromosome 4 encodes a short-chain dehydrogenase/reductase (SDR) family protein with NAD(P)-binding domain, possessing L-xylulose reductase (NADPH), carbonyl reductase (NADPH), sorbose reductase, mannitol 2-dehydrogenase (NADP+), and oxidoreductase activities acting on NAD(P)H with oxygen as acceptor. The gene is associated with L-sorbose breakdown, xylulose metabolism, mannitol metabolism, carbohydrate breakdown, glucose metabolism, and small molecule metabolism. It is linked to cellular homeostasis, protein homotetramerization, cell wall biogenesis, cell adhesion, filamentous growth, cell growth, and hypersensitivity. The product localizes to the vacuole. Studies of related genes in other species link the family to additional oxidoreductase activities (EC 1.1.1.10, 1.1.1.184, 1.1.1.138).