AFL1 — Candida albicans

Summary

C5_00180W_A (AFL1, also known as CaVIP1 or CaASP1) in Candida albicans encodes a protein with inositol hexakisphosphate 1-, 3-, 4-, and 6-kinase activity, 5-diphosphoinositol pentakisphosphate 1-kinase activity, diphosphatase and phosphatase activity, and belongs to the ATP-grasp RimK-type and histidine phosphatase superfamilies. The gene is associated with inositol phosphate metabolism and breakdown, energy homeostasis, regulation of autophagy, cell death, DNA damage response, and signaling. It is linked to numerous phenotypes including abnormal pseudohyphal and invasive growth, altered budding patterns, cell cycle progression defects, increased alkaline pH resistance, abnormal vacuolar distribution, and changes in chemical compound accumulation. The protein localizes to the cytoskeleton, cytosol, and nucleus. Studies of related genes in other species link the family to similar inositol phosphate signaling functions.