SNF1 — Candida albicans

Summary

C5_01320W_A (SNF1, CaSNF1) on Candida albicans chromosome 5 encodes a serine/threonine protein kinase with protein kinase A activity, containing AMPK_C, KA1/Ssp2_C, and protein kinase domains, and is associated with ATP binding, identical protein binding, and phospholipid binding. This gene is associated with energy homeostasis, regulation of carbohydrate metabolism, and the CAMKK-AMPK signaling cascade, as well as positive and negative regulation of pseudohyphal growth, regulation of invasive growth in response to glucose limitation, biofilm formation, cell aggregation, and fungal-type cell wall assembly. It localizes to the nucleotide-activated protein kinase complex, cellular bud neck septin ring, and vacuolar membrane. Phenotypic associations include altered cell cycle progression, biofilm formation, thermotolerance, carbon source utilization, and mating type switching. Studies of related genes in other species link the family to loss of pathogenicity and stress responses.