GLR1 — Candida albicans

Summary

C5_01520C_A (GLR1, also known as PGR1) in Candida albicans chromosome 5 encodes a protein with glutathione reductase activity and dihydrolipoyl dehydrogenase (NADH) activity, belonging to the GSHR/TRXR-like family and binding FAD and NADP. The gene is associated with cellular oxidant detoxification, cell redox homeostasis, glutathione metabolism and anabolism, lipid oxidation, response to glutathione and reactive oxygen species, nitrogen utilization and its regulation, 2-oxoglutarate metabolism, the pyruvate dehydrogenase pathway, phospholipid transport, phagocytosis, cellular respiration, nuclear import, G1 phase, and DNA anabolism. It localizes to mitochondria, the mitochondrial lumen, the pyruvate dehydrogenase complex, the glycine cleavage system, the KGDHC, peroxisomes, the cytosol, nucleus, and fungal biofilm matrix. Associations include respiration rate, oxidative stress response, and numerous phenotypes such as altered cell cycle progression, vegetative growth, pseudohyphal growth, mating response, apoptosis, and resistance to gamma rays, desiccation, freeze-thaw, osmotic stress, and starvation.