PUT1 — Candida albicans

Summary

C5_02600W_A (PUT1, CaPUT1) on Candida albicans chromosome 5 encodes a proline oxidase with FAD-linked oxidoreductase activity (EC 1.5.5.2), localizing to the mitochondria. The gene is associated with proline breakdown and metabolism, response to proline, amino acid and urea breakdown, arginine metabolism, oxidative phosphorylation, inflammatory response, invasive growth, and morphogenesis. Phenotypic associations include increased fermentative growth rate, increased freeze-thaw and hyperosmotic stress resistance, decreased cold sensitivity, increased viability, altered filamentous and invasive growth, abnormal budding and cell shape, decreased sporulation, and altered protein transport and mitochondrial genome maintenance. Related genes in other species are linked to increased desiccation resistance and innate thermotolerance.