CDR1 — Candida albicans

Summary

C5_02840C_A (CDR1, also known as HSL1) in Candida albicans encodes a dual-specificity protein kinase with protein kinase A activity, a serine/threonine kinase domain, and a fungal KA1 domain, and it also has signaling adaptor activity, membrane adaptor activity, and phospholipid binding activity. This gene is associated with hormone transport, aminophospholipid translocation, membrane polarization, reactive oxygen species anabolism, and regulation of cell growth extent. It is linked to the cellular bud neck, septin ring, mitotic spindle pole body, and nuclear membrane. Associations with traits include protein content and oxidative stress response, while phenotypes connect it to cell cycle progression through G2/M phase transition, cytokinesis, filamentous growth, mating efficiency, and osmotic stress resistance. Studies of related genes in other species link the family to cell cycle regulation and pathogenicity.