PRNC — Candida albicans

Summary

C5_04880C_A (PRNC, also known as PUT2) in Candida albicans chromosome 5 encodes a protein with L-glutamate gamma-semialdehyde dehydrogenase and aldehyde dehydrogenase (NAD+) activities, belonging to the P5CDH/ALDH4A1 and proline metabolism enzyme families. The gene is associated with proline breakdown and metabolism, response to proline, amino acid and urea breakdown, arginine metabolism, polyamine breakdown, ethanol breakdown, cellular detoxification of aldehyde, oxidative phosphorylation, invasive growth, and morphogenesis. It is linked to the mitochondrial lumen, mitochondria, cytoplasm, cytosol, nucleus, and Golgi complex. Associations with phenotypes include increased freeze-thaw and desiccation resistance, decreased viability, anaerobic growth, hyperosmotic and oxidative stress resistance, altered replicative and chronological lifespan, abnormal mitochondrial genome maintenance and vacuolar morphology, and altered competitive fitness and chemical resistance.